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Annexin A1在紫杉醇耐药卵巢癌中的表达及其临床意义
卵巢癌 Annexin A1 紫杉醇耐药
2014/9/1
探讨Annexin A1(ANXA1)在卵巢癌紫杉醇耐药细胞及组织中的表达，分析其与卵巢癌紫杉醇耐药及临床病理特征之间的关系。方法：采用Western 印迹及实时PCR方法检测卵巢癌紫杉醇耐药细胞株(SKOV3/Taxol-25)及敏感细胞株(SKOV3)中ANXA1的表达差异；采用免疫组织化学SP法检测42例卵巢癌标本中ANXA1蛋白的表达情况，结合临床资料分析ANXA1表达水平与卵巢癌紫杉醇耐...
钠依赖的葡萄糖转运蛋白2(sodium-dependent glucose transporters 2，SGLT2)是一种低亲和力、高容量的转运体，主要分布在肾脏近曲小管S1部位，负责肾脏中约90%葡萄糖的重吸收。因此，抑制SGLT2，阻止近曲小管对葡萄糖的重吸收，通过增加尿糖的排出来降低血糖已经成为糖尿病治疗的一种新的策略。文章简述了目前处于临床阶段的SGLT2抑制剂，重点阐述了第1个被FDA...
盐酸曲马多微球缓释片的制备及药动学研究
盐酸曲马多 微球 缓释片 生物利用度
2014/9/28
探讨盐酸曲马多微球缓释片的制备方法，并对微球缓释片在家犬体内药动学进行研究。方法 以乙基纤维素作为包裹材料，运用喷雾干燥法制备盐酸曲马多缓释微球，直接压片得到盐酸曲马多微球缓释片。对微球缓释片和市售缓释片进行家犬体内单剂量给药实验，建立高效液相分析方法。结果 HPLC显示方法精密度、回收率、专属性都符合要求。市售缓释片和微球缓释片的药动学参数Cmax分别为(322±16)ng·mL-1和(346±...
建立高效液相色谱-质谱(HPLC-MS/MS)法测定人血浆中伊伐布雷定及去甲伊伐布雷定浓度并用于人体药动学研究。方法 血浆样品处理均采用乙腈沉淀蛋白法，以地西泮为内标。质谱条件均采用电喷雾离子源(ESI)、正离子和多反应离子监测(MRM)模式进行检测。结果 本方法伊伐布雷定线性范围为0.096 7～145.050 0 ng/ml，r=0.997 1，最低定量浓度为0.096 7 ng/ml，去甲伊...
真空蒸汽润药法润制浙产三棱饮片的工艺研究
真空蒸汽润药 醇浸出物 总黄酮
2014/9/28
根据真空蒸汽润药原理，对浙产三棱进行气相置换软化，优化三棱润制工艺。方法 采用真空蒸汽润药机优化三棱润制工艺，并与传统润制方法进行比较。采用正交实验对润药工艺进行多因素考察，运用紫外分光光度法测定总黄酮的含量，以三棱醇浸出物和总黄酮的含量为综合评价指标，筛选最佳优化方案。结果 采用真空蒸汽润药软化后的三棱饮片含水量低，软化效果好，浸出物和总黄酮含量高。结论 真空蒸汽润药法可使药材在低含水量的情况下...
随着遗传药理学的迅速发展，越来越多的研究发现人类白细胞抗原(human leukocyte antigen，HLA)基因型与严重药物不良反应之间的关系，如已证实的HLA-B等位基因与阿巴卡韦、卡马西平、别嘌呤醇、拉莫三秦、氟氯西林等药物所致严重皮肤不良反应发生的风险相关。美国食品药物管理局(Food and Drug Administration，FDA)甚至已批准在阿巴卡韦和卡马西平药品标签中增...
A Small Group Assignment Gives Students a Novel Opportunity to Demonstrate Current Clinical Controversies in a Self-Care Course
pharmacy education self-care assessment nonprescription medications
2018/7/24
Objective. To design and implement a small-group assignment on current event, nonprescription drug therapy questions in a self-care course, and to evaluate student performance in predefined areas.
De...
An Eight-year Retrospective Study in“Flipped”Pharmacokinetics Courses
pharmacokinetics active learning blended learning
2018/7/24
Objective. To assess the impact on student performance of increased active learning strategies in a foundational pharmacokinetics course and a clinical pharmacokinetics course over an 8-year period.
...
姜黄素对鼻咽癌C666-1细胞增殖的抑制作用及其可能机制
雷帕霉素靶蛋白 C666-1细胞 增殖 凋亡
2014/7/18
观察姜黄素对鼻咽癌细胞株C666-1增殖及凋亡的影响，探讨其可能的作用机制。方法：0、10、25、50及100 μmol/L姜黄素作用24 h或50 μmol/L姜黄素不同时间（0、6、12及24 h）后， CCK-8法检测C666-1细胞的增殖情况，TUNEL法检测细胞凋亡，Western blotting检测不同浓度姜黄素作用24 h后细胞内AMPK、S6K1及S6蛋白磷酸化情况。结果：与0 ...
A Subgroup Analysis of the Impact of Self-testing Frequency on Examination Scores in a Pathophysiology Course
pharmacy education self-testing formative assessment active learning
2018/7/13
Objective: To determine if the frequency of self-testing of course material prior to actual examination improves examination scores, regardless of the actual scores on the self-testing.
Methods: Prac...
The Effectiveness of Psychoeducation and Systematic Desensitization to Reduce Test Anxiety Among First-year Pharmacy Students
psychological interventions test anxiety academic performance motivation pharmacy students
2018/7/13
Objective: To analyze the effect of psychological intervention on reducing performance anxiety and the consequences of the intervention on first-year pharmacy students.
Methods: In this experimental ...
A Faculty Toolkit for Formative Assessment in Pharmacy Education
formative assessment faculty development pharmacy education teaching-learning process
2018/7/13
This paper aims to increase understanding and appreciation of formative assessment and its role in improving student outcomes and the instructional process, while educating faculty on formative techni...
Development and Current Status of Clinical Pharmacy Education in China
Chinese clinical pharmacy education Chinese undergraduate programs Chinese graduate program postgraduate
2018/7/12
Objective. To describe the current status and developing trend of clinical pharmacy education in China.
Methods. Descriptive analysis of data and information about the clinical pharmacy specialty, ph...
An Active Learning Complementary and Alternative Medicine Session in a Self-Care Therapeutics Class
Complementary and alternative medicine (CAM) active learning, self-care
2018/7/10
Objective. To provide an interactive, non-supplement based complementary and alternative medicine (CAM) session in a self-care therapeutics class and to evaluate the effect of the session on pharmacy ...
Improved Knowledge Retention Among Clinical Pharmacy Students Using an Anthropology Classroom Assessment Technique
Classroom assessment techniques diabetes skills lab background knowledge probe
2018/7/10
Objective. To adapt a classroom assessment technique (CAT) from an anthropology course to a diabetes module in a clinical pharmacy skills laboratory and to determine student knowledge retention from b...