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哺乳动物的大脑由数目庞大、种类丰富的细胞所构成。不同细胞类型在分子、结构、功能等多个层面上彼此迥异,而这些差异往往是在神经发育过程中由精密的遗传程序指导所产生。近年来,各类新型遗传策略和工具的发明与应用,显著推进了神经环路的发育、连接、生理功能以及病理改变等各个方面研究的飞速发展,大大加深了我们对大脑功能的分子和细胞机制的认知。
近日,南方科技大学医学院助理教授贾宁在Nature Reviews Molecular Cell Biology在线发表题为“Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins”的综述文章,系统阐述了病毒anti-CRISPR 蛋白逃逸细菌CRISPR-Cas免疫系...
2021年5月8日,《Cellular and Molecular Life Science》在线发表了生物医学工程学院免疫成像与纳米诊疗团队的邀稿综述“基于纳米颗粒靶向淋巴系统的抗肿瘤治疗方法”(Nanoparticle-based approaches to target the lymphatic system for antitumor treatment, 2021, https://d...
Applications for this meeting must be submitted by May 13, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be st...
Across all scales, mechanical machines generate motion. That motion is characterized by the coherent change in location of one body with respect to another. Across all ages, we have been aware of the ...
Conference attendees are invited to attend the BiOS poster session on Monday evening. Come view the posters, enjoy light refreshments, ask questions, and network with colleagues in your field. Authors...
Posters will be on display Sunday and Monday with extended viewing until 9:00 pm on Sunday. The interactive poster session with authors in attendance will be Monday evening from 5:30 to 7:00 pm. Award...
Using a unique single-molecule force measurement tool, a research team has developed a clearer understanding of how platelets sense the mechanical forces they encounter during bleeding to initiate the...
2015年1月15日,浙江大学基础医学系刘伟教授研究组在Cell子刊Molecular Cell在线发表了论文“Deacetylation of nuclear LC3 drives autophagy initiation under starvation”,阐述了核内LC3蛋白脱乙酰化修饰在自噬泡形成中的重要意义及其调控机制。
This dissertation presents a body of research that attempts to tackle the ‘overfitting’ problem for gene signature and biomarker development in two different aspects (mechanistically and computational...
2010年3月28日,生物物理研究所江涛研究员课题组在 Nature Structural & Molecular Biology杂志在线发表了题为“Crystal Structure of the Carnitine Transporter and Insights into the Antiport Mechanism ”的文章。该研究解析了肉碱膜转运蛋白CaiT的三维结构,并对其分子机制进行...
Information technology research has played a significant role in the genomics revolution over the past decade, from aiding with large-scale sequence assembly to automating gene identification to ef...
Functional medical imaging promises powerful tools for the visualization and elucidation of important disease-causing biological processes in living tissue. Recent research aims to dissect the distrib...
We have synthesized and characterized gold nanoparticles (spheres and rods) with optical extinction bands within the “optical imaging window.” The intense plasmon resonant driven absorption and scatte...
Conjugate gradient method is verified to be efficient for nonlinear optimization problems of large-dimension data. In this paper, a penalized linear and nonlinear combined conjugate gradient method fo...

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