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Multi-scale analysis of morphology, mechanics, and composition of collagen in murine osteogenesis imperfecta
Atomic force microscopy Raman spectroscopy Reference point indentation MicroCT crystallinity modulus
2015/1/12
Osteogenesis imperfecta is a rare congenital disease commonly characterized by brittle bones caused by mutations in the genes encoding Type I collagen, the single most abundant protein produced by the...
Distribution of Type I Collagen Morphologies in Bone: Relation to Estrogen Depletion
AFM Ultrastructure disease diagnosis
2014/11/6
Bone is an amazing material evolved by nature to elegantly balance structural and metabolic needs in the body. Bone health is an integral part of overall health, but our lack of understanding of the u...
Type I Collagen Exists as a Distribution of Nanoscale Morphologies in Teeth, Bones and Tendons
collagen nanoscale morphologies bones
2014/11/6
This study demonstrates that collagen, the most abundant protein in animals, exists as a distribution of nanoscale morphologies in teeth, bones, and tendons. This fundamental characteristic of Type I ...