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THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ANTAGONIST, GW9662, ALTERS UVB-INDUCED INFLAMMATORY RESPONSES, APOPTOSIS, AND DELAYED HYPERPROLIFERATION
PPARγ UVB COX-2
2015/1/28
It has recently been shown that the gamma subtype of the peroxisome proliferator-activated receptor (PPARγ) is a target of ultraviolet B (290-320 nm; UVB) irradiation, and that PPARγ activation is nec...
Polyamines and Alveolar Macrophage Apoptosis during Pneumocystis Pneumonia
Polyamines Alveolar Macrophage Apoptosis Pneumocystis Pneumonia
2015/1/28
Pneumocystis pneumonia (PCP) is the leading opportunistic disease in immunocompromised individuals, particularly in AIDS patients. The alveolar macrophage (AM) is the major type of cell responsible fo...
A STUDY OF THE BETA-2 TOXIN GENE AND THE BETA-2 TOXIN IN CLOSTRIDIUM PERFRINGENS STRAINS ISOLATED FROM HUMAN SOURCES
Clostridium perfringens beta-2 toxin
2015/1/28
Clostridium perfringens is an important human pathogen known to cause a range of diseases including diarrhea, necrotizing bowel disease and gas gangrene. Though potentially pathogenic, this microorgan...
THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ANTAGONIST, GW9662, ALTERS UVB-INDUCED INFLAMMATORY RESPONSES, APOPTOSIS, AND DELAYED HYPERPROLIFERATION
PPARγ UVB COX-2
2015/1/19
It has recently been shown that the gamma subtype of the peroxisome proliferator-activated receptor (PPARγ) is a target of ultraviolet B (290-320 nm; UVB) irradiation, and that PPARγ activation is nec...
Effect of Shear Stress on RhoA Activities and Cytoskeletal Organization in Chondrocytes
Biomedical Engineering
2015/1/12
Mechanical force environment is a major factor that influences cellular homeostasis and remodeling. The prevailing wisdom in this field demonstrated that a threshold of mechanical forces or deformatio...
MOLECULAR PROFILING IN BREAST CANCER AND TOXICOGENOMICS
molecular profiling,breast cancer toxicogenomics feature selection
2015/1/9
This dissertation presents a body of research that attempts to tackle the ‘overfitting’ problem for gene signature and biomarker development in two different aspects (mechanistically and computational...
A PROBABILISTIC APPROACH TO DATA INTEGRATION IN BIOMEDICAL RESEARCH: THE IsBIG EXPERIMENTS
Probabilistic Models Biomedical Research Bayesian Networks
2015/1/9
Biomedical research has produced vast amounts of new information in the last decade but has been slow to find its use in clinical applications. Data from disparate sources such as genetic studies and ...
Advancing Toxicology-Based Cancer Risk Assessment with Informatics
carcinogenecity informatics risk assessment
2015/1/9
Since exposure to carcinogens can occur in the environment from various point sources, cancer risk assessment attempts to define and limit potential exposure such that the risk of developing cancer is...
Translational research has proven to be a powerful process that bridges the gap between basic science and medical practice. The complexity of translational research is two-fold: integration of vast am...
Reported evidence suggested that high abundance of intrinsic disorder in eukaryotic genomes in comparison to bacteria and archaea may reflect the greater need for disorder-associated signaling and tra...
瑞典生命科学发展现状
瑞典 生命科学 生物和医药技术 生命科学产业
2015/5/12
当前，生命科学领域的发展已成为全球关注的焦点。很多国家都将生命科学列为重点发展领域 之一。瑞典在生命科学研究领域一直保持国际先进水平，生命科学产业是瑞典主要的出口产业。面对日趋激烈的国际竞争，瑞典政府发布“2013-2016 年研究与创新法案”，宣布投资 19.6 亿克朗支持生命科学发展，重点研究方向包括：传染病和抗生素研究、老年病研究、药物研发、临床治疗技术改进以及临床实验研究等。本文分析了瑞典...
医学研究中的恢复力系统模型
医学研究 恢复力 系统模型
2014/9/30
恢复力指从疾病或灾祸中恢复的能力。临床医师和公众对人类健康状况的理解已经逐渐从关注病理学现象（聚焦于疾病）转向为关注“健康”本身，科学界也越来越多地关注于有助于保护个体和社会健康的相关因素。对恢复力的研究是这项关键转变的一个基本方面，在理解和解读人们对压力和创伤经验中复杂多因扰动进行的应答来说，也是一条充满希望的途径。快速变化的全球性政治经济和环境状况，需要人们跨学科、更有效地理解恢复力研究，并寻...
Exercise Training Improves Heart Rate Variability after Methamphetamine Dependency
HRV SUBSTANCE,USE AUTONOMIC,NERVOUS,SYSTEM PARASYMPATHETIC,ACTIVITY
2017/5/23
Heart rate variability (HRV) reflects a healthy autonomic nervous system and is increased with physical training. Methamphetamine dependence (MD) causes autonomic dysfunction and diminished HRV. We co...
Aβ42基因在大肠杆菌中的表达及诱导BALB/c小鼠的抗体产生
大肠杆菌 Aβ42 可溶性蛋白
2014/6/24
研究纯化大肠杆菌中Aβ42蛋白的表达情况，并探索该蛋白接种小鼠后抗体的产生情况。方法 构建表达载体pGEX-4T-1-Aβ42，设置不同的诱导温度来进行Aβ42在大肠杆菌中表达。用SDS-PAGE、GST柱及Western blot来鉴定纯化目的蛋白。动物实验中，用福氏佐剂采用背部多点注射的方式免疫BALB/c小鼠3次。间接ELISA法检测免疫小鼠血清和脑组织匀浆上清液中特异性抗体的滴度。结果 在...