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Accurate, nonintrusive, and feasible methods are needed to predict energy expenditure (EE) and physical activity (PA) levels in preschoolers. Herein, we validated cross-sectional time series (CSTS) an...
Variable airway function is a central feature of the asthmatic condition. Thus, habitually active asthmatics are certain to exercise under conditions of variable airway (dys)function. The purpose of t...
This study aimed to examine the effects of intermittent isometric fatigue on maximal voluntary contraction (MVC) strength, percent voluntary activation (%VA), peak twitch force (PTF), peak rate of for...
Several studies have documented significant associations between sedentary behaviors such as sitting or television viewing and premature mortality. However, the associations between mortality and othe...
总结近期国内外有关miRNA在乳腺癌化疗耐药中作用的研究进展。应用Pubmed和CNKI期刊全文数据库检索系统以“miRNA、乳腺癌和化疗耐药”为关键词,检索2000年1 月至2012年10月有关在乳腺癌化疗耐药中作用的文献。从乳腺癌化疗耐药入手,阐述乳腺癌化疗耐药的特点、机制,并着重对miRNA在乳腺癌化疗耐药中的作用进行分析。miRNA通过多种途径参与乳腺癌的化疗耐药。本文具体综述了一些以不同...
观察脂肪来源干细胞(adipose-derive stem cells, ASCs)植入放射损伤骨骼肌后的纤维化程度改变,探讨ASCs对兔骨骼肌放射性纤维化的影响。方法 64只新西兰兔单侧臀部予9 MeV电子线单次照射80 Gy后,采用随机数字表法分为ASCs组和PBS组,每组32只,照射24 h后照射侧分别肌肉注射1 ml含5×107 ASCs的PBS悬液和1 ml PBS缓冲液,未照射一侧作为...
Numerous prospective studies indicate that improved cardiorespiratory fitness reduces type 2 diabetes risk and delays disease progression. We hypothesized that genetic variants modify fitness response...
Childhood cancer survivors (CCS) experience late effects that interfere with physical function. Limitations in physical function can affect CCS abilities to actively participate in daily activities. T...
Moderate-intensity physical activity is recommended for individuals with diabetes to control glucose and prevent diabetes-related complications. The extent to which a diabetes diagnosis motivates pati...
Disruption of autonomic control after spinal cord injury (SCI) results in life-threatening cardiovascular dysfunctions and impaired endurance performance; hence, an improved ability to recognize those...
Purpose: Screening programs and greater public awareness have increased the recognition of early abdominal aortic aneurysm (AAA) disease. No medical therapy has proven effective in limiting AAA progre...
PI3K in juvenile myelomonocytic leukemia     JMML  PI3K   PTPN11  Shp2  p110 delta       2015/5/21
Juvenile Myelomonocytic Leukemia (JMML) is rare, fatal myeloproliferative disease (MPD) affecting young children, and is characterized by expansion of monocyte lineage cells and hypersensitivity to Gr...
《美国病理学杂志》9月10日公布的一项新研究显示,H7N9禽流感病毒能够同时有效感染上下呼吸道,这种感染模式在禽流感病毒中尚属首次发现。这说明H7N9病毒具有在人际间有效传播并导致严重肺炎从而引起大流行的潜在可能。
对一例层黏连蛋白α2缺失型先天性肌营养不良(MDC1A)患儿LAMA2基因突变(c.7147C>T/p.Arg2383X、c.6513_6515delTGT/p.2172delVal)进行报道和分析。方法 提取一例MDC1A患儿与其父母的外周血DNA,PCR扩增LAMA2基因的全部65个外显子,以琼脂糖凝胶电泳鉴定PCR产物,PCR产物纯化后进行直接基因测序。结果 检测到先证者LAMA2基因的多种...
系统评价雄激素在卵巢低反应患者体外受精治疗周期妊娠结局中的作用。方法 电子检索Cochrane Library、CENTRAL、PUBMED、MEDLINE、EMBASE、中国知网、万方及维普等中外文数据库,收集已公开发表的比较联合应用雄激素与不联合应用雄激素对卵巢低反应患者体外受精治疗周期妊娠结局影响的临床随机对照研究。由两名独立研究员按照Cochrane系统评价员手册对纳入文献进行筛选、数据提...

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