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Seven male patients, aged 26 to 42 years (mean age, 33.1 years), participated. All patients reported generalized urticaria and dyspnea; 5, loss of consciousness; 2, collapse; 2, vomiting; and 2, diarr...
蛋白酶激活受体(protease-activated receptors, PARs)属G蛋白耦联受体家族,目前共发现4个成员:PAR1、PAR2、PAR3和PAR4。蛋白酶可以酶切PARs的N末端,暴露含有系锁配体的新的N末端,可自我激活PARs功能,激活的PARs引起信号级联反应,最终影响细胞的形状、参与细胞的分泌、整合蛋白的活化、代谢反应、转录过程及细胞运动等多种功能。PARs分布在多种组织...
Vα14 natural killer T (NKT) cells produce large amounts of both IL-4 and IFN-γ upon stimulation with a ligend, α-galactosylceramide (α-GalCer), and play a crucial role in various immune responses, inc...
Preadministration of antihistamine eye drops suppressed the symptoms induced by the allergen, which suggests that this is an effective early therapy for Japanese cedar pollinosis, if it is started bef...
Background: We investigated the early efficacy of topical levocabastine, an H1 histamine-receptor antagonist, in improving the clinical symptoms of allergic conjunctivitis. Methods: Thirty-six patien...
Vernal keratoconjunctivitis (VKC), a severe form of ocular allergic disease, is characterized by the formation of giant papillae at the upper tarsal conjunctiva and corneal lesions that threaten visio...
LTB4, a proinflammatory lipid mediator generated from arachidonic acid through the action of 5-lipoxygenase, has been known for over two decades and is implicated in a wide variety of inflammatory dis...
Food allergy, triggered by an aberrant immune response elicited by orally ingested food allergens, is generated through a complicated mechanism because the allergen interacts with the mucosal immune s...
The case history of a 27-year-old man with Matsutake mushroom-dependent anaphylactoid reaction is reported. The patient suffered from general cutaneous erythema, with itching, urticaria angiedema to h...
An allergic response to foreign intestinal antigens such as those contained in food has been implicated as a causative factor in the development of inflammatory bowel disease (IBD). In this study, we ...
We demonstrated that chemical mediators including histamine, tryptase and ECP as well as several cytokines were involved significantly during the episode of anaphylaxis. In addition, eosinophils as we...
The present paper reports on a 26-year-old atopic patient suffering from seasonal rhinoconjunctivitis and flexural eczemas. On two occasions, he experienced nausea, generalized urticaria and dyspnea w...
Recombinant pollen allergens rPhlp1, rPhlp2, rPhlp5, and rBetv2 may function as effective markers of atopy and account for a substantial proportion of grass pollen-specific IgE. The purpose of the pre...
Mold-specific IgE was elevated by EIA (> 0.35 IU/mL) to at least one of the 10 studied species in 12 children (39%) with and in two children (3%) without skin test reactions. The calculated prevalence...
We wanted to define allergen-specific antibodies that change due to specific immunotherapy. We conducted a study with grass pollen-allergic patients and compared allergen-specific IgE and IgG4 before ...

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