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广州医科大学张玉霞团队《Cell》发文揭示新生儿胆道闭锁发病机制及免疫疗法（图）
新生儿 胆道闭锁 发病机制 免疫疗法
2021/1/12
人类的免疫系统起始于受精2-3周时的卵黄囊（Yolk sac），在3-4周时胚胎的Aorta-Gonad-Mesonephros（AGM，主动脉-性腺-中肾）区也出现造血干细胞。随后，卵黄囊和主动脉干细胞迁移至胎肝，胎肝造血功能在7-17周达到峰值，在20周左右衰退。在11周时，前体细胞进入骨髓，20周后骨髓成为主要的造血器官。近日，广州医科大学附属广州市妇女儿童医疗中心儿科研究所的张玉霞教授团队...
2020年11月27日，我校附属妇女儿童医疗中心（广州市妇女儿童医疗中心）儿科研究所张玉霞教授团队，外科实验室温哲、夏慧敏教授团队和北京大学生物医学前沿创新中心白凡教授团队关于胆道闭锁（biliary atresia, BA）发病机制和治疗方法的联合研究成果“Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Bilia...
Repression of cyclin D1 as a target for germ cell tumors
metastatic germ cell tumors cyclin D1
2014/12/12
Metastatic germ cell tumors (GCT) are curable, however GCTs refractory to cisplatin-based chemotherapy have a poor prognosis. This study explores D-type cyclins as molecular targets in GCTs because al...
Yeast apurinic/apyrimidinic endonuclease Apn1 protects mammalian neuronal cell line from oxidative stress
DNA repair gene therapy
2014/12/12
Reactive oxygen species (ROS) have been implicated as one of the agents responsible for many neurodegenerative diseases. A critical target for ROS is DNA. Most oxidative stress-induced DNA damage in t...
Knockdown of the DNA repair and redox signaling protein Ape1/ Ref-1 blocks ovarian cancer cell and tumor growth
base excision repair APE1/Ref-1 ovarian cancer
2014/12/12
Apurinic endonuclease 1/redox effector factor-1 (Ape1/Ref-1 or Ape1) is an essential protein with two distinct functions. It is a DNA repair enzyme in the base excision repair (BER) pathway and a redu...
Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization
Rac Cdc42
2014/12/12
Critical to homeostasis of blood cell production by hematopoietic stem/progenitor (HSC/P) cells is the regulation of HSC/P retention within the bone marrow microenvironment and migration between the b...
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics
mast cells Pak1 allergic diseasis
2014/12/12
Mast cells are key participants in allergic diseases via activation of high-affinity IgE receptors (FcϵRI) resulting in release of proinflammatory mediators. The biochemical pathways linking IgE...
Cell Metab：科学家发现糖尿病的新致病原因（图）
Cell Metab 科学家 糖尿病 致病原因
2014/3/19
xeter Medical Schoo大学研究人员日前揭示了新生儿糖尿病的两个新的遗传原因。他们完成的这项研究发表在Cell Metabolism杂志上，进一步揭示了β细胞在胰腺中如何形成。研究小组发现，对胰腺发育重要的两个特定基因的基因突变后，可引起新生儿糖尿病。这些发现将新生儿糖尿病的遗传原因数量增至20个。论文主要作者Sarah Flanagan表示：我们非常自豪能够给予参与研究的家庭解答，...
An 18-year Follow-up of Allergy Development Related to Nasal Metachromatic Cell Findings During Infancy
allergy cohort study metachromatic cells nasal epithelium prediction
2010/11/12
The cumulative number of subjects with allergy was 46, probable allergy 5, and no allergy 13. Detected MCinfancy predicted allergy with high accuracy (31/33), but negative MCinfancy findings did not e...
Identification of Hitherto Undefined B-Cell Epitopes by Antibodies in the Sera of Vitiligo Patients Using Phage-Display Peptide Library
B-cell Epitope Random Peptide Library Self-antigen
2010/4/22
A random 12 mers phage library was used to screen a pool of immunoglo¬bulin fractions obtained from vitiligo patients. Subsequent to panning experiments, a panel of affinity selected phage from vi...
B-cell Lineage Study in Patients with Juvenile Idiopathic Arthritis
B-cell Lineage Immunophenotyping Juvenile idiopathic arthritis Chronic Arthritis
2009/12/17
Objective: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. The exact causes of disease are still poorly understood. It seems that B cells have several functions i...
Short Term Reactogenicity of a Triple Diphtheria-Tetanus-Whole Cell Pertussis Vaccine in Iranian Infants
Diphtheria-Tetanus-Pertussis Vaccine Vaccination Reactogenicity Infant Local reaction Systemic reaction Iran
2009/12/14
Background: Immunization against diphtheria, tetanus and pertussis (DTP) has long been applied in Iran using whole cell vaccine. Despite the role of whole cell DTP (DTwP) vaccine in reduction of ...