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Omega-3 long-chain PUFA intake during pregnancy and allergic disease outcomes in the offspring: a systematic review and meta-analysis of observational studies and randomized controlled trials
allergic disease n–3 LC-PUFA pregnancy allergy prevention fatty acids randomized controlled trial prenatal supplementation asthma eczema hayfever
2018/11/23
Background: There is some evidence that increased maternal intake of omega-3 (n–3) long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may reduce the incidence of immunoglobulin E (IgE)...
Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials
dietary guidance blood lipids blood lipoproteins blood pressure animal flesh meat products diet meat
2018/11/12
Background: Observational associations between red meat intake and cardiovascular disease (CVD) are inconsistent. There are limited comprehensive analyses of randomized controlled trials (RCTs) that i...
Best (but oft-forgotten) practices: sensitivity analyses in randomized controlled trials
analysis commentary sensitivity statistics tutorial
2018/11/23
Arandomized controlled clinical trial is the best way to minimize bias in ascertaining treatment effects, but the credibility of the results of a trial depends on the validity of the methods used to a...
Issues in Conducting Randomized Controlled Trials of Health Services Research Interventions in Nonacademic Practice Settings: The Case of Retail Pharmacies
pharmaceutical care randomized trial
2014/12/11
Objective. To describe unexpected challenges and strategies to overcome them when conducting randomized controlled trials (RCT) of health services research interventions in retail pharmacies. Study Se...
Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis: systematic review and meta-regression
multiple sclerosis relapses annualized relapse rates placebo baseline characteristics eligibility criteria meta-analysis meta-regression systematic review
2013/4/27
Background: Recent studies have shown a decrease in annualised relapse rates (ARRs) in placebo groups of randomised controlled trials (RCTs) in relapsing multiple sclerosis (RMS).
Methods: We conduc...