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Every day, billions of red blood cells pass through the spleen, an organ that is responsible for filtering out old or damaged blood cells. This task is made more difficult when the blood cells are mis...
Humoral immunity and haemoglobin F (HbF) status in steady state adult Nigerian sickle cell disease patients with asymptomatic malaria
Sickle cell disease malaria parasitaemia immunoglobulins inflammation haemolysis
2010/1/11
Aim: Nigeria, where malaria is prevalent, has the largest sickle cell gene pool in the world. To this end, there is a need for increased understanding of the pathophysiology of HbSS patients in a mala...
A Longitudinal Examination Predicting Emergency Room Use in Children with Sickle Cell Disease and Their Caregivers
emergency room utilization perceptions of disease sickle cell disease
2008/3/25
Objective To examine in a longitudinal investigation perceptions of disease severity among children and adolescents with sickle cell disease (SCD) and their caregivers and to determine whether percept...
Brief Report: Daily Mood as a Mediator or Moderator of the Pain–Sleep Relationship in Children with Sickle Cell Disease
diary mood pain sickle cell disease sleep
2009/12/21
Objective To investigate mood as a mediator or moderator of the pain-sleep relationship in children with sickle cell disease (SCD). Method Children with SCD (n = 20; aged 8–12 years) completed daily d...