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浙江大学生命科学研究院2022年1月17日沈立实验室在Leukemia合作发文解析HMCES对长期造血干细胞的保护作用并提出白血病治疗的新靶点（图）
沈立 造血干细胞 白血病治疗 新靶点
2022/10/25
长期造血干细胞（long-term hematopoietic stem cell, LT-HSC）通过自我更新和多向分化维持机体的终身造血。在稳态下，这群稀有的成体干细胞通过保持静息状态以减少活性氧（ROS）的产生从而保证其基因组的稳定性。然而，当遭受造血压力刺激时，LT-HSC会退出静息状态并快速活化和增殖，从而导致细胞内的ROS水平迅速升高，进而产生无碱基位点（AP位点）等DNA氧化损伤。当...
近日，我校在读博士王莹、李护君，及朱峰副教授在CAR-T疗法的临床研究方面取得了新的进展，相关结果分别发表在血液学领域权威期刊《Leukemia》（JCR 1区 TOP期刊 IF：9.9）和《Bone Marrow Transplantation》（JCR 1区）。论文题目：Safety and efficacy of chimeric antigen receptor (CAR)-T-cell ...
Researchers find new clue to halting leukemia relapse
Researchers halting leukemia relapse
2015/9/18
A protein domain once considered of little importance may be key to helping patients who are fighting acute myeloid leukemia (AML) avoid a relapse.Researchers at Rice University, working wit...
Chronic Myeloid Leukemia with Variant Chromosomal Translocations:Results of Treatment with Imatinib Mesylate
Chronic myeloid leukemia Imatinib Variant translocation
2015/7/10
Objective: To evaluate the efficacy of imatinib in chronic myeloid leukemia patients with variant translocations. Methods: Forty eight chronic myeloid leukemia patients carrying variant translocations...
西安交通大学医学院血液系统疾病课件 Leukemia
西安交通大学医学院 血液系统疾病 课件 Leukemia
2014/8/4
西安交通大学医学院血液系统疾病课件 Leukemia。
杨仁池、张磊课题组在Leukemia期刊发表文章“Analysis of calreticulin mutations in Chinese patients with essential thrombocythemia: clinical implications in diagnosis, prognosis and treatment”
Juvenile Myelomonocytic Leukemia (JMML) is rare, fatal myeloproliferative disease (MPD) affecting young children, and is characterized by expansion of monocyte lineage cells and hypersensitivity to Gr...
Successful Treatment of Life-Threatening Cerebral Bleeding Associated with Disseminated Intravascular Coagulation Using Recombinant Human Soluble Thrombomodulin in a Patient with Mixed Phenotype Acute Leukemia with t (9; 22) (q34; q11.2); Bcr-Abl1
Mixed Phenotype Acute Leukemia with t (9 22) (q34 q11.2) Bcr-Abl1
2013/1/29
Recently, mixed phenotype acute leukemia (MPAL) with t (9; 22) (q34; q11.2); bcr-abl1 was described as one kind of acute leukemia of ambiguous lineage in the 2008 World Health Organization Classificat...
Obesity and childhood survivors of acute lymphoblastic leukemia: Do genetics play a role?
Genetic Polymorphisms Obesity Metabolic Syndrome Acute Lymphoblastic Leukemia
2013/1/30
Childhood survivors of acute lymphoblastic leukemia (ALL) are increased risk of several chronic complications, such as second cancers, pulmonary, metabolic complications and cardiovascular disease. Ob...
Guillain-Barré-like Syndrome,as a Rare Presentation of Adult T-cell Leukemia-Lymphoma (ATLL):A Case Report
Guillain-Barré Syndrome Human T-lymphotropic virus 1 Leukemia-Lymphoma Adult T-Cell
2015/9/28
We report a 21-year-old woman who was admitted because of unilateral facial paresis and then developed progressive ascending flaccid tetraparesis with generalized areflexia. Electrodiagnostic studies ...
中国医学科学院实验血液学国家重点实验室王建祥课题组在Leukemia期刊上发表"PIG7, transactivated by AML1, promotes apoptosis and differentiation of leukemia cells with AML1-ETO fusion gene"
血液学 国家重点实验室 王建祥 课题组 Leukemia期刊
2012/2/23
中国医学科学院实验血液学国家重点实验室王建祥课题组在在Leukemia期刊发表文章"PIG7, transactivated by AML1, promotes apoptosis and differentiation of leukemia cells with AML1-ETO fusion gene.”
Initial Presentation of Acute Lymphoblastic Leukemia with Osteoporosis and Multiple Spontaneous Bone Fractures
Acute lymphoblastic leukemia Osteoporosis Bone fracture Iran
2015/9/22
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Skeletal abnormalities have been described in association with ALL including osteoprosis and bone fractures. Different facto...
The Prevalence and Clinical Significance of Anticardiolipin Antibody in Acute Myeloblastic Leukemia
Anticardiolipin antibody Acute myeloblastic leukemia Clinical significance Iran
2015/9/21
Background: Antiphospholipid antibodies, including lupus anticoagulants and anticardiolipin (aCL) antibodies are associated with a wide variety of disorders including malignancies. The aim of this stu...
Juvenile Dermatomyositis Associated with Acute Lymphocytic Leukemia
Juvenile dermatomyositis Leukemia Leukemia Malignancy
2009/7/3
A link between dermatomyositis and neoplasia has long been suspected. The precise incidence of this association remains controversial, owing to varying criteria used to diagnose dermatomyositis. Altho...