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搜索结果: 1-9 共查到Leptin相关记录9条 . 查询时间(0.13 秒)
探讨瘦素(leptin)对人脑胶质瘤U87MG细胞迁移及侵袭能力的影响及其机制。方法:Leptin处理U87MG细胞,采用细胞划痕实验检测U87MG细胞的迁移能力,Transwell实验检测U87MG细胞的侵袭能力,RT-PCR及Western blotting法检测U87MG细胞中MMP-2及MMP-9 mRNA和蛋白的表达。结果:Leptin明显促进U87MG细胞迁移能力\[(152.42±3...
Background: Leptin is an adipocyte- derived hormone that plays an important role in the pathogenesis of obesity. Obesity is associated with insulin resistance and hyperinsulinemia. Insulin resistance ...
Leptin is a 16-kD protein which is secreted from white adipocytes and, its discovery has generated enormous interest in the regulation of energy balance. Leptin has been implicated in the regulation o...
Aim: Adipocytokines are now considered important players in the etiopathogenesis of numerous metabolic and inflammatory disorders. However, plasma leptin and resistin levels in rheumatoid arthritis (R...
Aim: Although there is evidence of a positive association between psoriasis and body mass index (BMI) and leptin is known to play a part in the regulation of the immune system, the relationship betwee...
Background: It is assumed that leptin affects the circulatory system. The aim of this study was to assess the influence of chronic, dynamic and static physical effort on leptin levels and regional d...
目的: 研究瘦素(leptin)在肝缺血/再灌注(H-I/R)后肠道内的表达变化, 并探讨leptin在H-I/R介导的肠道损伤中的作用. 方法: 建立大鼠70% H-I/R模型, 大鼠随机分成5组, 每组9只, 依次为假手术(Sham)组、肝缺血60 min/再灌注60 min (I60'R60')组、I60'R150'组、I60'R240'组和I60'R360'组. 采用酶比色法检测损伤后血清...
抗精神病药物治疗可引起明显的体重增加,因此增加了患糖尿病、高血压等与肥胖相关疾病的机会,也导致患者服药依从性差。抗精神病药物引起体重增加的机制目前仍不清楚。本课题正是为了探讨利培酮及氯氮平治疗精神分裂症前后患者血清Leptin和PRL浓度的变化及与体重变化的关系。方法:测量两组患者服药前后的体重,同时用放射免疫法测量两组患者服药前后血清Lept in和PRL的浓度。结果显示:两组患者治疗后体重均明...
Background: Pregnancy and accelerated fetal growth always are related with major metabolic changes and body fat redistribution and adiponectin is one of principle adipocyte hormones, so studying adipo...

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