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慢性胰腺炎是一种进行性纤维化炎症疾病，其特点是炎症的反复发作和广泛的胰腺组织纤维化。慢性胰腺炎发病率逐年升高，但其发病机制尚未完全阐明。探究胰腺炎组织纤维化的诱发机制可以为胰腺炎疾病的预防和治疗开辟新的潜在策略。近日，上海中医药大学附属龙华医院杨旭光与复旦大学上海医学院的林玉丽团队展开合作研究，从基质细胞代谢过程调节免疫微环境这一新视角出发，深度剖析了慢性胰腺炎组织纤维化的诱发机制，在国际顶级免疫...
慢性胰腺炎是一种进行性纤维化炎症疾病，其特点是炎症的反复发作和广泛的胰腺组织纤维化。慢性胰腺炎发病率逐年升高，但其发病机制尚未完全阐明。探究胰腺炎组织纤维化的诱发机制可以为胰腺炎疾病的预防和治疗开辟新的潜在策略。近日，上海中医药大学附属龙华医院的杨旭光团队与复旦大学上海医学院的林玉丽团队展开合作研究，从基质细胞代谢过程调节免疫微环境这一新视角出发，深度剖析了慢性胰腺炎组织纤维化的诱发机制，在国际顶...
重症新冠肺炎患者的人体免疫防御路径发生“变道”，在这个过程中究竟发生了什么？3月8日，上海交通大学医学院附属仁济医院风湿科中澳个体化免疫研究中心卡罗拉·维努埃萨课题组在国际顶级免疫学期刊《Immunity》发表评述文章，从多角度探讨人体B细胞发育路径在各种病理条件下的不同作用，为感染和自身免疫病的防治提供了新的靶点和方向。
二型天然淋巴细胞是天然免疫的重要参与者，主要介导二型免疫反应，在过敏、哮喘等疾病的发病机制中发挥重要作用，是近年来免疫学领域的研究热点之一。利用木瓜蛋白酶诱导的急性哮喘模型, 研究者发现，在天然淋巴细胞前体中选择性基因敲除泛素连接酶冯•希伯-林岛蛋白VHL基因，肺组织中二型天然淋巴细胞数量明显减少，其介导的肺部二型炎症反应也显著减弱。进一步的研究表明，泛素连接酶缺失导致细胞中其主要底物...
免疫和炎症反应参与神经损伤和重建的许多环节，因而成为神经系统许多疾病诊断和治疗的重要靶标。在这些神经系统疾病中，脑卒中（包括脑梗死和脑出血）自2010年已经超越心血管疾病和恶性肿瘤成为我国居民致死、致残的首要病因。缺血性脑卒中急性发生后约21-65%的患者并发感染，以肺部和尿路感染最为常见，是这些患者的主要死因之一（约占20%）和不良预后相关的重要危险因素。
Cell系列顶级期刊Immunity发表西南大学淡水鱼类资源与生殖发育教育部重点实验室罗凌飞教授研究团队最新研究成果
Cell系列顶级期刊Immunity 西南大学淡水鱼类资源与生殖发育教育部重点实验室 教授研究团队 脑血管损伤修复
2016/5/4
2016年5月3日，Cell系列顶级期刊Immunity（《免疫》，影响因子21.561）在线发表了西南大学生命科学学院、西南大学淡水鱼类资源与生殖发育教育部重点实验室罗凌飞教授研究团队在脑血管损伤修复领域的最新研究成果《Macrophages Mediate the Repair of Brain Vascular Rupture through Direct Physical Adhesion...
Epidemiologic observations have linked an increased risk of colorectal cancer (CRC)3 and inflammatory bowel disease with distance from the equator (1–3). Notably, inflammatory bowel disease is a risk ...
Exercise Intensity and Duration Effects on In Vivo Immunity
STRESS RUNNING IMMUNE CONTACT HYPERSENSITIVITY DIPHENCYPRONE IRRITANT
2017/4/19
Purpose: To examine the effects of intensity and duration of exercise stress on induction of in vivo immunity in humans using experimental contact hypersensitivity (CHS) with the novel antigen dipheny...
Clock Generation and Distribution for Enhancing Immunity to Power Supply Noise
Clock microprocessor core microprocessor clock frequency the power supply
2014/11/7
Clock generation and distribution are getting difficult due to increased die size and increased number of cores in a microprocessor. Clock frequencies of microprocessors have been increased and expect...
Humoral immunity and haemoglobin F (HbF) status in steady state adult Nigerian sickle cell disease patients with asymptomatic malaria
Sickle cell disease malaria parasitaemia immunoglobulins inflammation haemolysis
2010/1/11
Aim: Nigeria, where malaria is prevalent, has the largest sickle cell gene pool in the world. To this end, there is a need for increased understanding of the pathophysiology of HbSS patients in a mala...
Major League Baseball Anti-Trust Immunity: Examining the Legal and Financial Implications of Relocation Rules
Antitrust law Collective Bargaining Agreement Franchise Relocation Major League Baseball Revenue Sharing Territorial Rights
2009/12/25
This paper investigates the legal, policy, and financial considerations concerning Major League Baseball’s territorial rules. Specifically, it addresses antitrust law as it pertains to American profes...
Acute stress augments innate immunity in the liver and increases hyaluronan levels in the tissues and blood of mice
increases hyaluronan levels blood of mice
2009/12/16
The effect of acute stress on the immune system was examined in mice. Restraint stress decreased the number of lymphocytes in the liver, whereas the number of lymphocytes remained unchanged in the spl...
Cancer Immunity and Trace Elements
cancer immunity trace elements carcinogenesis tumor progress tumor suppression anticancer agent
2009/4/1
In this article, the connection modes between cancer immunity and trace elements are reviewed, with a focus on the three wide fields of the carcinogenesis, the tumor progress and the tumor suppression...
Immunomodulating effect of vitamin D3 derivatives on type-1 cellular immunity
vitamin D3 type-1 cellular immunity
2009/3/2
1α,25-dihydroxyvitamin D3 [Calcitriol or 1,25(OH)2D3] is an important active metabolite involved in multiple functions but its calcemic effect in vivo limits its therapeutic applications. On the oth...
Potentiation of intestinal immunity by micellary mushroom extracts
intestinal immunity micellary mushroom extracts
2009/3/2
Mushroom (shiitake) extracts were dispersed with lecithin micelles to prepare superfine particles (0.05 to 0.2 μm in diameter) of β-1,3-glucan (micellary mushroom extracts). When mice were fed with ...