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氯吡格雷是使用最广泛的P2Y12血小板抑制剂,然而,部分患者存在氯吡格雷抵抗。2020年美国心脏病学杂志(JACC)子刊发表了一项研究提出了ABCD-GENE评分量表的构建。ABCD-GENE评分量表纳入包括年龄、身体质量指数(BMI)、肾功能、糖尿病病史在内的临床因素和CYP2C19基因型,以更精确的识别氯吡格雷药效学反应较低的人群。
再审申请人(一审被告、二审上诉人):抚州市创世纪科技有限公司,住所地江西省抚州市抚州高新技术产业开发区文昌大道以西、高新五路以北森鸿产业园13、14幢。法定代表人:许志杰,该公司执行董事。委托诉讼代理人:赵建英,北京市中伦文德律师事务所律师。委托诉讼代理人:万小明,江西联创律师事务所律师。被申请人(一审原告、二审上诉人):GenesisMiningLimited,住所地香港特别行政区湾仔告士打道1...
评价Gene Xpert结核分枝杆菌/利福平(MTB/RIF,简称"Xpert")在人类免疫缺陷病毒(HIV)阴性肠结核患者早期快速诊断中的价值。方法:选取2018年1月至2019年6月在山东省胸科医院、北京胸科医院、苏州市第五人民医院3家医院就诊的254例HIV阴性疑似肠结核患者。采集所有患者的粪便标本,每份标本分别进行Xpert检测、涂片查抗酸杆菌、BACTEC MGIT 960(简称"MGI...
探讨Gene Xpert MTB/RIF检测(简称Xpert检测)在结核性胸膜炎诊断及利福平耐药检测中的应用价值。方法 回顾性分析2016年7月1日至2018年7月31日在西安市胸科医院外科就诊的86例初步诊断为结核性胸膜炎患者和同期 34例诊断为非结核胸膜炎患者的胸腔积液标本,分别行抗酸染色、BACTEC MGIT 960液体快速培养、荧光定量PCR和Xpert检测,对比4种方法检测结核分枝杆菌...
Background: Variations in intestinal antioxidant membrane transporters are implicated in the initiation and progression of inflammatory bowel disease (IBD). Facilitated glucose transporter member 14 (...
On average, children from less economically privileged households have lower levels of educational attainment than their higher-income peers, and this association has important implications for interg...
Introduction: Phenylketonuria (PKU) is an autosomal recessive inborn error of phenylalanine metabolism, which is caused by mutation in phenylalanine hydroxylase (PAH) gene. Most of the PAH mutations a...
Multiple myeloma (MM) is a cancer of antibody-making plasma cells. It frequently harbors alterations in DNA and chromosome copy numbers, and can be divided into two major subtypes, hyperdiploid (HMM) ...
Important theoretical models in contemporary health psychology have concentrated on environmental risk factors, such as norms and behaviours of peers and family members, to explain health behaviours. ...
Multiple myeloma (MM) is a cancer of antibody-making plasma cells. It frequently harbors alterations in DNA and chromosome copy numbers, and can be divided into two major subtypes, hyperdiploid (HMM) ...
Background: The relationship between decreased activity/neuropathic pain and gene expression alterations in soleus muscle has remained elusive.
Background: Atherosclerotic cardiovascular disease is currently a cause of mortality in some parts of the world. The ATP-Binding Cassette Transporter (ABCA1) gene prepares instructions to produce the ...
Genes can be activated or inhibited by signals within the tissues in response to an acute bout of exercise. It is unclear how a particular aerobic exercise bout may influence two muscles with similar ...
Clostridium perfringens is an important human pathogen known to cause a range of diseases including diarrhea, necrotizing bowel disease and gas gangrene. Though potentially pathogenic, this microorgan...

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