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科学家发现DHA调节脑神经发育新机制
二十二碳六烯 神经元质膜 脑神经发育
2022/3/31
二十二碳六烯酸（DHA）是神经元质膜的重要组成部分。在大脑皮层灰质区，DHA主要存在于质膜磷脂，但同时也可在磷脂酶的作用下从膜上释放下来，以游离方式或通过其衍生物参与多种信号转导。
DHA促进大脑神经发育的机制（图）
DHA 大脑 神经发育
2020/5/20
2020年5月19日，《Cell Reports》期刊在线发表了题为《类视黄醇X受体α调节DHA依赖的树突棘发育和功能性突触形成的在体机制》的研究论文，该研究由中国科学院脑科学与智能技术卓越创新中心（神经科学研究所）、神经科学国家重点实验室于翔研究组完成。该研究结合在体基因操纵（转基因小鼠、病毒注射和胚胎电转等）、药理学、荧光染料微注射、RNA测序、脑片电生理及行为学等实验，发现了大脑内游离DHA...
DHA-rich n–3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study
fish oil DHA EPA DNA methylation LINE-1 Alzheimer disease
2018/11/20
Background: Dietary fish oils, rich in long-chain n–3 (ω-3) fatty acids (FAs) [e.g., docosahexaenoic acid (DHA, 22:6n–3) and eicosapentaenoic acid (EPA, 20:5n–3)], modulate inflammatory reactions thro...
Prenatal supplementation with DHA improves attention at 5 y of age: a randomized controlled trial
attention child development fatty acids prenatal supplementation omega-3 fatty acids preschool cognitive development
2018/12/14
Background: Docosahexanoic acid (DHA) is an important constituent of the brain. Evidence from well-designed intervention trials of the long-term benefits of increasing DHA intake during pregnancy has ...
Prenatal supplementation with DHA improves attention at 5 y of age: a randomized controlled trial
attention child development fatty acids prenatal supplementation omega-3 fatty acids preschool cognitive development
2018/12/18
Background: Docosahexanoic acid (DHA) is an important constituent of the brain. Evidence from well-designed intervention trials of the long-term benefits of increasing DHA intake during pregnancy has ...
A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study
DHA EPA inflammation men and women randomized controlled trial risk factors
2018/12/13
Background: To date, most studies on the anti-inflammatory effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in humans have used a mixture of the 2 fatty acids in various forms and...
Maternal single nucleotide polymorphisms in the fatty acid desaturase 1 and 2 coding regions modify the impact of prenatal supplementation with DHA on birth weight
birth weight DHA FADS long-chain PUFAs prenatal supplementation
2018/11/29
Background: Specific single nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene affect the activity and efficiency of enzymes that are responsible for the conversion of polyunsatu...
Long-term effect of high-dose supplementation with DHA on visual function at school age in children born at <33 wk gestational age: results from a follow-up of a randomized controlled trial
docosahexaenoic acid DHA preterm infant very preterm visual processing
2018/11/26
Background: Children born preterm are at risk of visual-processing impairments. Several lines of evidence have contributed to the rationale that docosahexaenoic acid (DHA) supplementation of preterm i...
DHA- Rich Fish Oil Improves Complex Reaction Time in Female Elite Soccer Players
Fatty acids omega 3 efficiency decision-making
2015/5/7
Omega-3 fatty acids (n-3) has shown to improve neuromotor function. This study examined the effects of docosahexaenoic acid (DHA) on complex reaction time, precision and efficiency, in female elite so...
对缩减轮数DHA-256的原像与伪碰撞攻击
DHA-256散列函数 原像攻击 伪碰撞攻击 中间相遇攻击
2014/3/21
提出了对DHA-256散列函数37轮的原像攻击以及39轮的伪碰撞攻击。基于中间相遇攻击，利用Biclique方法可以改进之前对DHA-256的原像分析结果，将攻击轮数从原来的35轮提高到了37轮。通过上述方法还可以构造对DHA-256的39轮伪碰撞。最终，以2255.5的时间复杂度以及23的空间复杂度构造了对DHA-256的37轮原像，并以2127.5的时间复杂度以及常数2的空间复杂度构造了对DH...
DHA对人肝癌细胞增殖与凋亡的影响及其机制的研究
癌 肝细胞 二十二碳六烯酸类 细胞凋亡
2014/5/11
探讨二十二碳六烯酸（DHA）对人肝癌细胞株Bel-7402增殖和凋亡的影响及其机制。方法：用不同浓度的DHA（0，25，50，100，200 μmol/L）分别作用人肝癌Bel-7402细胞24，48，72 h后，用MTT法检测细胞的增殖情况、Western blot检测Bcl-2和Bax蛋白的表达，并分别用流式细胞仪、real-time PCR和caspase-3活性检测试剂盒检测上述梯度浓度的...
DHA无助于减缓老年认知障碍
DHA 老年 认知障碍
2011/10/11
很多老年人都服用鱼油保健品，因为其中的主要成分之一DHA是一种对大脑十分重要的成分。但美国一项最新研究却认为，DHA无助于减缓老年轻度至中度认知障碍。DHA是一种不饱和脂肪酸，大量存在于大脑中，被誉为“脑黄金”。此前很多研究都认为，DHA可以预防或减缓阿尔茨海默氏症等老年认知障碍。但俄勒冈卫生科学大学等机构的研究人员完成的最新调查却认为，一旦被诊断出患上了阿尔茨海默氏症，即便再补充DHA，也无益处...
美研究称补充DHA无助减缓老年认知障碍
DHA 老年认知障碍
2010/11/5
很多老年人都服用鱼油保健品，因为其中的主要成分之一DHA是一种对大脑十分重要的成分。但美国一项最新研究却认为，DHA无助于减缓老年轻度至中度认知障碍。
富含EPA或DHA海洋微藻胶囊开发技术
微藻胶囊 海洋药物
2008/12/16
1.课题来源及背景：高度不饱和脂肪酸(pUFA)，尤其是N-3系列的廿碳五烯酸(epA)和廿二碳六烯酸(DHA)具有很强的生理活性，是人和动物生长、发育所必需的脂肪酸。它们具有抗血栓、防止血小板聚结、舒张血管、降低胆固醇和甘油三酯等作用。海洋微藻是海洋中的初级生产力，具有合成epA、DHA的奇特能力，鱼和其他海洋动物自身不能合成epA和DHA，它们是通过食物链(即海洋微藻→浮游动物→鱼及其他的海洋...