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Silver Ion-Coated Medical Devices Could Fight MRSA While Creating New Bone
Silver Ion-Coated Medical Devices Fight MRSA Creating New Bone
2017/3/13
Methicillin-resistant Staphylococcus aureus (MRSA) infections are caused by a type of staph bacteria that has become resistant to the antibiotics used to treat ordinary staph infections. The rise of M...
Experimental and Computational Analysis of Dynamic Loading for Bone Formation
Biomechanics Mechanical Loading Bone Formation Resonance
2015/1/12
Bone is a dynamic tissue that is constantly remodeling to repair damage and strengthen regions exposed to loads during everyday activities. However, certain conditions, including long-term unloading o...
Signaling Pathways Involved in Mechanical Stimulation and ECM Geometry in Bone Cells
Mechanical Stimulation Osteoblast ECM
2015/1/12
The proliferation and differentiation of osteoblasts are influenced by mechanical and geometrical growth environments. A specific aim of my thesis was the elucidation of signaling pathways involved in...
Ultrastructural elastic deformation of cortical bone tissue probed by NIR Raman spectroscopy
Raman bone biomechanics
2014/11/6
Raman spectroscopy is used as a probe of ultrastructural (molecular) changes in both the mineral and matrix (protein and glycoprotein, predominantly type I collagen) components of murine cortical bone...
Exercise-Induced Changes in the Cortical Bone of Growing Mice Are Bone and Gender Specific
mechanical properties pQCT matrix changes
2014/11/6
Fracture risk and mechanical competence of bone are functions of bone mass and tissue quality, which in turn are dependent on the bone's mechanical environment. Male mice have a greater response to no...
Exercise Alters Mineral and Matrix Composition in the Absence of Adding New Bone
Mechanical loading Mechanical properties Mineral Collagen Raman spectroscopy
2014/11/6
The mechanical properties of bone are dictated by its amount, distribution and ‘quality’. The composition of the mineral and matrix phases is integral to defining ‘bone quality’. Exercise can potentia...
Distribution of Type I Collagen Morphologies in Bone: Relation to Estrogen Depletion
AFM Ultrastructure disease diagnosis
2014/11/6
Bone is an amazing material evolved by nature to elegantly balance structural and metabolic needs in the body. Bone health is an integral part of overall health, but our lack of understanding of the u...
Inbred Strain-Specific Response to Biglycan Deficiency in the Cortical Bone of C57BL6/129 and C3H/He Mice
inbred mice mech anical properties mCT PCR Raman histomorphometry
2014/11/6
Inbred strain-specific differences in mice exist in bone cross-sectional geometry, mechanical properties, and indices of bone formation. Inbred strain-specific responses to external stimuli also exist...
Elevated Mechanical Loading When Young Provides Lifelong Benefits to Cortical Bone Properties in Female Rats Independent of a Surgically Induced Menopause
d mechanical loading exercise menopause bone properties
2014/11/6
Exercise that mechanically loads the skeleton is advocated when young to enhance lifelong bone health. Whether the skeletal benefits of elevated loading when young persist into adulthood and after men...
Applications of atomic force microscopy for the assessment of nanoscale morphological and mechanical properties of bone
Atomic Force Microscopy Scanning probe microscopy
2014/11/6
Scanning probe microscopy (SPM) has been in use for 30 years, and the form of SPM known as atomic force microscopy (AFM) has been around for 25 of those years. AFM has been used to produce high resolu...
Nanoscale Changes in Collagen are Reflected in Physical and Mechanical Properties of Bone at the Microscale in Diabetic Rats
Zucker diabetic Sprague-Dawley Atomic Force Microscopy Raman Spectroscopy Reference Point Indentation D-spacing Advanced Glycation End Products
2014/11/6
Diabetes detrimentally affects the musculoskeletal system by stiffening the collagen matrix due to increased advanced glycation end products (AGEs). In this study, tibiae and tendon from Zucker diabet...
Bone cell-independent benefits of raloxifene on the skeleton: A novel mechanism for improving bone material properties
Raloxifene mechanicaltesting toughness water
2014/11/6
Raloxifene is an FDA approved agent used to treat bone loss and decrease fracture risk. In clinical trials and animal studies, raloxifene reduces fracture risk and improves bone mechanical properties,...
Cortical Bone Mechanical Properties Are Altered in an Animal Model of Progressive Chronic Kidney Disease
chronic kidney disease whole bone mechanical properties
2014/11/6
Chronic kidney disease (CKD), which leads tocortical bone loss and increasedporosity,increases therisk of fracture. Animal models have confirmed that these changes compromise whole bone mechanical pro...
Multi-scale Analysis of Bone Chemistry, Morphology and Mechanics in the oim Model of Osteogenesis Imperfecta
Atomic force microscopy Raman Spectroscopy Reference Point Indentation MicroCT Crystallinity Modulus
2014/11/6
Osteogenesis imperfecta is a congenital disease commonly characterized by brittle bones and caused by mutations in the genes encoding Type I collagen, the single most abundant protein produced by the ...
Microcomputed Tomography Applications in Bone and Mineral Research
Bone CT Mineralization Vascularization BMD Modeling
2014/11/6
Microcomputed tomography (μCT) has evolved as a development of simple X-ray imaging into an indispensable technique used in both laboratory research and clinical diagnostics. Commercially available sy...