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THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ANTAGONIST, GW9662, ALTERS UVB-INDUCED INFLAMMATORY RESPONSES, APOPTOSIS, AND DELAYED HYPERPROLIFERATION
PPARγ UVB COX-2
2015/1/28
It has recently been shown that the gamma subtype of the peroxisome proliferator-activated receptor (PPARγ) is a target of ultraviolet B (290-320 nm; UVB) irradiation, and that PPARγ activation is nec...
Polyamines and Alveolar Macrophage Apoptosis during Pneumocystis Pneumonia
Polyamines Alveolar Macrophage Apoptosis Pneumocystis Pneumonia
2015/1/28
Pneumocystis pneumonia (PCP) is the leading opportunistic disease in immunocompromised individuals, particularly in AIDS patients. The alveolar macrophage (AM) is the major type of cell responsible fo...
THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ANTAGONIST, GW9662, ALTERS UVB-INDUCED INFLAMMATORY RESPONSES, APOPTOSIS, AND DELAYED HYPERPROLIFERATION
PPARγ UVB COX-2
2015/1/19
It has recently been shown that the gamma subtype of the peroxisome proliferator-activated receptor (PPARγ) is a target of ultraviolet B (290-320 nm; UVB) irradiation, and that PPARγ activation is nec...
Vernonia amygdalina—Induced Growth Arrest and Apoptosis of Breast Cancer (MCF-7) Cells
Vernonia amygdalina MCF-7 Cells Apoptosis Necrosis Cellometer Imaging
2013/2/19
Breast cancer is the second leading cause of cancer-related deaths of women in the United States. Fortunately, the mortality rate from breast cancer has decreased in recent years due to an increased e...
Reactive oxygen species induced oxidative stress, neuronal apoptosis and alternative death pathways
Apoptosis Caspases Cell Death Mitochondria PCBs Reactive Oxygen Species
2013/1/28
Reactive oxygen species (ROS) are produced as a byproduct of cellular metabolic pathways and function as a critical second messenger in a variety of intracellular signaling pathways. The excessive int...
Role of Calcium Signals on Hydrogen Peroxide-Induced Apoptosis in Human Myeloid HL-60 Cells
caspases calcium signal apoptosis mitochondria H2O2 HL-60 cells
2009/10/26
The present study is aimed to determine the role of calcium signaling evoked by the oxygen radical, hydrogen peroxide (H2O2) and the specific inhibitor of calcium reuptake thapsigargin on apoptosis in...
Engineered FADD Induces Apoptosis via an Artificial Death-Inducing Signaling Complex (DISC)
apoptosis FADD biotechnology DISC engineered protein
2009/10/26
An engineered Fas-associated death domain protein (FADD), 2DEDplusE—made previously by fusing the tandem DEDs of FADD to the E protein of lambda phage-greatly enhances apoptosis-inducing activity in a...
Induction of apoptosis in human bladder cancer cells by green tea catechins
apoptosis human bladder cancer cells
2009/12/16
Cell culture and animal studies have demonstrated strong chemopreventative effects of green tea and its associated polyphenols in multiple cancers, though the exact mechanisms of action are not well u...
Differentiation-associated alteration in sensitivity to apoptosis induced by (-)-epigallocatechin-3-O-gallate in HL-60 cells
Differentiation-associated alteration sensitivity
2009/12/16
Green tea and its constituent (-)-epigallocatechin-3-O-gallate (EGCG) are known to have apoptosis-inducing activity on tumor cells including human leukemia HL-60 cells, providing an explanation for th...
Role of Raf-1 kinase in Diabetes-induced Accelerated Apoptosis of Retinal Capillary Cells
apoptosis diabetic retinopathy endothelial cells Raf-1 small molecular weight G-protein
2009/4/29
Small molecular weight G-proteins serve as fundamental signaling switches that regulate cell fates by coupling receptor activation to downstream effector pathways. H-Ras, a small molecular weight G-pr...
Lidocaine-induced apoptosis and necrosis in U937 cells depending on its dosage
Lidocaine-induced apoptosis U937 cells
2009/3/3
Local anesthetics are known to affect a variety of cellular responses other than the action of anesthetics through the Na+ channel blockade. In this study, we examined the effect of a common local ane...
Protection of hepatocytes from apoptosis by a novel substance from actinomycetes culture medium
hepatocytes apoptosis novel substance actinomycetes culture medium
2009/3/2
A novel substance, #675, found from an Streptomyces sp. SM675 culture medium, dose-dependently stimulates the proliferation of human functional liver cell 4 (FLC4). When FLC4 cells were incubated un...
Induction of cell cycle arrest and apoptosis in JAR trophoblast by antimalarial drugs
cell cycle arrest apoptosis JAR trophoblast antimalarial drugs
2009/3/2
Chloroquine, quinine, artemisinin, and pyrimethamine are generally considered safe drugs for treatment of malaria during pregnancy; however, high doses of these drugs are detrimental with adverse ou...
Geldanamycin, a heat-shock protein 90-binding agent, induces thymocyte apoptosis through destabilization of Lck in presence of 12-O-tetradecanoylphorbol 13-acetate
Geldanamycin heat-shock protein 90-binding agent destabilization of Lck 12-O-tetradecanoylphorbol 13-acetate
2009/3/2
Geldanamycin, a heat-shock protein 90 (Hsp90)-binding agent, modulates various cellular activities. The present study found that, although geldanamycin by itself had no effect on thymocyte viability...
The effects of dexmedetomidine on human neutrophil apoptosis
dexmedetomidine human neutrophil apoptosis
2009/3/2
The purpose of the present study was to evaluate the effect of dexmedetomidine, used as a sedative in the intensive care unit, on human neutrophil apoptosis and superoxide production in vitro. Neutr...