搜索结果: 1-15 共查到“生物医学工程 Collagen”相关记录15条 . 查询时间(0.106 秒)
Multi-scale analysis of morphology, mechanics, and composition of collagen in murine osteogenesis imperfecta
Atomic force microscopy Raman spectroscopy Reference point indentation MicroCT crystallinity modulus
2015/1/12
Osteogenesis imperfecta is a rare congenital disease commonly characterized by brittle bones caused by mutations in the genes encoding Type I collagen, the single most abundant protein produced by the...
Effects of Collagen Gel Stiffness on Cdc42 Activities of Endothelial Colony Forming Cells during Early Vacuole Formation
ECFC Vacuole Cdc42 Stiffness FRET
2015/1/12
Recent preclinical reports have provided evidence that endothelial colony forming cells (ECFCs), a subset of endothelial progenitor cells, significantly improve vessel formation, largely due to their ...
Distribution of Type I Collagen Morphologies in Bone: Relation to Estrogen Depletion
AFM Ultrastructure disease diagnosis
2014/11/6
Bone is an amazing material evolved by nature to elegantly balance structural and metabolic needs in the body. Bone health is an integral part of overall health, but our lack of understanding of the u...
Type I Collagen Exists as a Distribution of Nanoscale Morphologies in Teeth, Bones and Tendons
collagen nanoscale morphologies bones
2014/11/6
This study demonstrates that collagen, the most abundant protein in animals, exists as a distribution of nanoscale morphologies in teeth, bones, and tendons. This fundamental characteristic of Type I ...
Nanoscale Morphology of Type I Collagen is Altered in the Brtl Mouse Model of Osteogenesis Imperfecta
AFM nanoscale
2014/11/6
Bone has a complex hierarchical structure that has evolved to serve structural and metabolic roles in the body. Due to the complexity of bone structure and the number of diseases which affect the ultr...
Effects of tissue hydration on nanoscale structural morphology and mechanics of individual Type I collagen fibrils in the Brtl mouse model of Osteogenesis Imperfecta
AFM Ultrastructure Genotype/phenotype D-periodic spacing Modulus Energy
2014/11/6
Type I collagen is the most abundant protein in mammals, and is a vital part of the extracellular matrix for numerous tissues. Despite collagen’s importance, little is known about its nanoscale morpho...
Nanoscale Structure of Type I Collagen Fibrils: Quantitative Measurement of D-spacing
Collagen fibril D-spacing 2D FFT AFM
2014/11/6
This article details a quantitative method to measure the D-periodic spacing of type I collagen fibrils using atomic force microscopy coupled with analysis using a two-dimensional fast fourier transfo...
Nanoscale Changes in Collagen are Reflected in Physical and Mechanical Properties of Bone at the Microscale in Diabetic Rats
Zucker diabetic Sprague-Dawley Atomic Force Microscopy Raman Spectroscopy Reference Point Indentation D-spacing Advanced Glycation End Products
2014/11/6
Diabetes detrimentally affects the musculoskeletal system by stiffening the collagen matrix due to increased advanced glycation end products (AGEs). In this study, tibiae and tendon from Zucker diabet...
Urinary type IV collagen excretion predicts an increased urinary albumin-to-creatinine ratio in normoalbuminuric patients with diabetes
Type IV Collagen Diabetic Nephropathy Oxidative Stress Monocyte Chemoattractant Protein-1
2013/1/30
Aims: We evaluated whether urinary excretion of type IV collagen (U-COL) may predict an increase in the urinary albumin-to-creatinine ratio (ACR) and what factors regulate U-COL in 145 normoalbuminuri...
The instantaneous deformation of cartilage: effects of collagen fiber orientation and osmotic stress
cartilage collagen fiber orientation osmotic stress
2010/1/7
The instantaneous deformation of cartilage: effects of collagen fiber orientation and osmotic stress.
Development of Bio-actuator with Tissue-engineered Skeletal Muscle Regenerated on Acellular Tissue and Collagen Gel
tissue-engineered skeletal muscle bio-actuator, C2C12 cell, photofabrication isometric contractile force
2009/6/2
A tissue-engineered muscle has a potential to realize a flexible actuator with high efficiency as a bioactuator, whereas mechanical actuators currently used are inflexible and low efficiency. In this ...
An in vitro assay of collagen fiber alignment by acupuncture needle rotation
collagen fiber alignment acupuncture needle rotation
2010/2/25
These results indicate that the mechanostructural properties of soft connective tissues may affect their response to acupuncture therapy. The in vitro model provides a platform to study mechanotransdu...
Crosslinking by advanced glycation endproducts increases the stiffness of the collagen network in human articular cartilage
advanced glycation endproducts the collagen network human articular cartilage
2010/1/7
Crosslinking by advanced glycation endproducts increases the stiffness of the collagen network in human articular cartilage.
The increased swelling and instantaneous deformation of osteoarthritic cartilage is highly correlated with collagen degradation
osteoarthritic cartilage collagen degradation
2010/1/7
The increased swelling and instantaneous deformation of osteoarthritic cartilage is highly correlated with collagen degradation.
Dynamic Mechanical Conditioning of Collagen-Gel Blood Vessel Constructs Induces Remodeling In Vitro
Tissue engineering Vascular Mechanical properties Cyclic strain Remodeling
2010/1/7
Dynamic mechanical conditioning is investigated as
a means of improving the mechanical properties of tissueengineered
blood vessel constructs composed of living cells
embedded in a collagen-gel sca...