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Cost-Effectiveness of an Emergency Department Based Early Sepsis Resuscitation Protocol
sepsis emergency medicine
2014/11/28
Background Guidelines recommend that sepsis be treated with an early resuscitation protocol, such as early goal directed therapy (EGDT). Our objective was to assess the cost-effectiveness of implement...
Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis Therapy: A Randomized Clinical Trial
sepsis septic shock emergency medicine mortality
2014/11/28
Context Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department. Objective To test the hypothesis of noninferiorit...
Prognostic Value and Agreement of Achieving Lactate Clearance or Central Venous Oxygen Saturation Goals During Early Sepsis Resuscitation
Fibrin fragment D venous thromboembolism medical decision making tomography spiral computed
2014/11/28
Objectives: Lactate clearance (LC) and central venous oxygen saturation (ScvO2) have been proposed as goals of early sepsis resuscitation. The authors sought to determine the agreement and prog...
Outcomes of Patients Undergoing Early Sepsis Resuscitation for Cryptic Shock Compared with Overt Shock
septic shock lactate resuscitation emergency medicine mortality
2014/11/28
Introduction We sought to compare the outcomes of patients with cryptic versus overt shock treated with an emergency department (ED) based early sepsis resuscitation protocol. Methods Pre-planned seco...
Plasma Levels of Mitochondrial DNA in Patients Presenting to the Emergency Department with Sepsis
Sepsis SIRS mtDNA mitochondrial DNA inflammation
2014/11/28
Introduction Elevated levels of plasma mitochondrial DNA (mtDNA) have been reported in trauma patients, and may contribute to the systemic immune response. We sought to determine the plasma levels of ...
The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation
sepsis severe sepsis scoring system Sequential Organ Failure Assessment mortality
2014/11/28
Objectives Organ failure worsens outcome in sepsis. The Sequential Organ Failure Assessment (SOFA) score numerically quantifies the number and severity of failed organs. We examined the utility of the...
One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study
sepsis septic shock emergency medicine mortality
2014/11/28
Introduction Early structured resuscitation of severe sepsis has been suggested to improve short term mortality; however, no previous study has examined the long-term effect of this therapy. We sought...
The significance of non-sustained hypotension in emergency department patients with sepsis
hypotension sepsis emergency medicine
2014/11/28
Objective Few studies have documented the incidence and significance of non-sustained hypotension in emergency department (ED) patients with sepsis. We hypothesized that ED non-sustained hypotension i...
Prospective External Validation of the Clinical Effectiveness of an Emergency Department-Based Early Goal-Directed Therapy Protocol for Severe Sepsis and Septic Shock
early goal-directed therapy emergency department resuscitation sepsis septic shock
2014/11/28
Objective: To determine the clinical effectiveness of implementing early goal-directed therapy (EGDT) as a routine protocol in the emergency department (ED). Methods: Prospective interventional study ...
Performance of the Mortality in emergency department Sepsis score for predicting hospital mortality among patients with severe sepsis and septic shock
sepsis septic shock mortality emergency department MEDS score
2014/11/28
Objective The aim of the study was to test if the Mortality in Emergency Department Sepsis (MEDS) score accurately predicts death among emergency department (ED) patients with severe sepsis and septic...
The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: A meta-analysis
sepsis septic shock mortality resuscitation meta-analysis
2014/11/28
Objective Quantitative resuscitation consists of structured cardiovascular intervention targeting predefined hemodynamic end points. We sought to measure the treatment effect of quantitative resuscita...