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Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-alpha in the Rat
cyclooxygenase-2 COX-2 COX-1 prostaglandin E2 neuroinflammation blood-brain barrier ischemia stroke matrix metalloproteinase MMP-3 MMP-9 gelatinase B stromelysin-1 oxidative stress indomethacin cyclooxygenase-1 glutathione free radicals MRI
2015/7/29
Increased permeability of the blood-brain barrier (BBB) is important in neurological disorders. Neuroinflammation is associated with increased BBB breakdown and brain injury. Tumor necrosis factor-alp...
Comparison of Alpha Blockers in Treatment of Premature Ejaculation: A Pilot Clinical Trial
Premature Ejaculation Quality of Life Serotonin Uptake Inhibitors
2015/10/9
Background:: Premature ejaculation (PE) is the most common sexual disorder in men and studies reported prevalence up to 30% (1, 2). PE is not a life-threatening medical condition but it influences the...
探讨SM22α与骨桥蛋白（OPN）以及细胞骨架蛋白α-SMA，β-tubulin，desmin在腹主动脉瘤（AAA）组织中的表达改变。 方法：采集正常人腹主动脉壁和AAA动脉壁组织，分别采用real-time PCR与免疫组织化学法检测两种组织中SM22α，OPN，α-SMA，β-tubulin和desmin的mRNA与蛋白表达水平。 结果：与正常腹主动脉壁组织比较，AAA组织中的SM22α，α-...
目的: 探讨核因子-kappaB(nuclear factor-kappa B, NF-kappaB)及其下游因子TNF-alpha、Bcl-2在急性肝损伤的作用及机制. 方法: ♂Wistar大鼠90只随机分为正常组, 硫代乙酰胺(TAA)造模组及脯氨酸二硫代氨基甲酸酯(PDTC)预处理组(n = 30). 三组大鼠分别于造模完成后6、24、48 h 3个时间点处死, 每个时间点各取10只大鼠....