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Targeting Human Mast Cells Expressing G-Protein-Coupled Receptors in Allergic Diseases
allergic diseases bronchial asthma GPCRs human mast cells urticaria
2010/11/17
The G-protein-coupled receptors (GPCRs) are the largest known group of integral membrane receptor proteins and are the most common targets of pharmacotherapy. Mast cells (MCs) have been reported to pl...
Role of α-Galactosylceramide-activated Vα14 Natural Killer T Cells in the Regulation of Allergic Diseases
IFN-γ IgE Th2 responses Vα14 NKT cell α-Galactosylceramide
2010/11/18
Vα14 natural killer T (NKT) cells produce large amounts of both IL-4 and IFN-γ upon stimulation with a ligend, α-galactosylceramide (α-GalCer), and play a crucial role in various immune responses, inc...
Risk factors for asthma and allergic diseases among 13-14-year-old schoolchildren in Japan
allergy asthma childhood International Study of Asthma and Allergies in Childhood prevalence risk factor
2010/11/24
In analyses of family histories, the odds ratios (OR) of children who have a family history with no symptoms were significantly lower by risk factor-based analyses compared with those children with a ...
Role of dendritic cells in Th1/Th2 balance: A novel therapeutic target of allergic diseases
dendritic cell monocyte chemotactic protein-1 OX40 ligand regulatory T cells Th2
2010/11/22
Considerable evidence supports the role of dendritic cells (DC) in the pathogenesis of allergic diseases. Dendritic cells, as the most potent antigen-presenting cells (APC) for the induction of primar...
Effects of Probiotics on the Immune System and Allergic Diseases
adaptive immunity allergic diseases commensals epithelial cells innate immunity intestinal microbiota probiotics
2010/11/22
Intestinal microbiota play a crucial role in the development of mucosal tolerance and adaptation. Perturbations in microbiota composition are strongly associated with allergies and asthma in westerniz...
CpG Oligodeoxynucleotides as a Future Vaccine for Allergic Diseases
antigen-specific bronchial asthma dendritic cell Th1/Th2 cell
2010/11/19
An astounding feature of the DNA sequences termed CpG motifs is the induction of immune and inflammatory responses in a senseless manner. CpG motifs exist abundantly in microbes and evoke innate immun...