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首都医科大学附属北京天坛医院王伊龙教授团队《Neurology》揭示氧化LDL可预测轻型卒中及TIA复发(图)
首都医科大学附属北京天坛医院 王伊龙 教授 Neurology 氧化LDL 可预测 轻型卒中 TIA复发
2019/1/16
2018年9月,首都医科大学附属北京天坛医院王伊龙教授团队在《Neurology》(IF:8.515)发表题为" Oxidized Low-density Lipoprotein Predicts Recurrent Stroke in Patients with Minor Stroke or TIA "的论文。研究团队通过探索氧化低密度脂蛋白(oxLDL)与轻型卒中和短暂性脑缺血发作(TIA)...
Cashew consumption reduces total and LDL cholesterol: a randomized, crossover, controlled-feeding trial
cardiovascular cashew cholesterol clinical trial hypercholesterolemia
2018/11/13
Background: Cashews are the third most-consumed tree nut in the United States and are abundant with monounsaturated fatty acids and polyunsaturated fatty acids, which are associated with reduced cardi...
研究2型糖尿病患者血清中小而密低密度脂蛋白胆固醇(sdLDL-C)水平与脂类代谢紊乱的情况,并了解胰岛素治疗对脂类代谢的影响。方法 受试者分为正常组400例(男195例,女205例),2型糖尿病193例(男108例,女85例)按脂类代谢情况将2型糖尿病患者分为下列亚组:血脂正常亚组33例、高胆固醇血症亚组(总胆固醇≥5.18 mmol/L)21例、高甘油三酯血症亚组(甘油三酯≥1.7 mmol/L...
SIRT3 siRNA对ox-LDL刺激的人主动脉内皮细胞ICAM-1、E-selectin表达的影响
SIRT3 siRNA 人主动脉内皮细胞 细胞间黏附分子-1 E-选择素 氧化型低密度脂蛋白
2014/6/4
探讨SIRT3基因对氧化型低密度脂蛋白(ox-LDL)刺激的人主动脉内皮细胞(HAEC)炎性因子细胞间黏附分子-1(ICAM-1)、E-选择素(E-selectin)表达的影响。方法 将生长状态良好的细胞随机分为空白对照组、转染试剂对照组、阴性对照组及SIRT3 siRNA(1、2、3、4)组。筛选出最佳序列后,细胞分为空白对照组、siRNA组、(20、30、40μg/mL)ox-LDL组、si...
探讨载脂蛋白嵌合模拟肽Ac-hE-18A-NH2对氧化型低密度脂蛋白(oxidized LDL,ox-LDL)刺激下巨噬细胞肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)表达的影响及其作用机制。方法:Ox-LDL刺激RAW264.7巨噬细胞,给予不同浓度的模拟肽Ac-hE-18A-NH2(1~100 μg/mL)干预,收集细胞,测定巨噬细胞TNF-α的分泌和mRNA...
瑞舒伐他汀是目前经临床试验证实能够稳定并逆转动脉粥样硬化病变进展的他汀类药物,本实验主要探讨药物干预后基质金属蛋白酶(MMP)-2,9在动脉粥样硬化斑块稳定中的机制。方法 人单核细胞株(THP-1)经佛波酯(PMA)诱导贴壁为巨噬细胞后,利用氧化型低密度脂蛋白(ox-LDL)80 mg/L与巨噬细胞共同孵育,分别给予不同药量(0,2,4,7和10 ng/ml)的瑞舒伐他汀进行干预,应用RT-PCR...
Association between Serum Levels Of Hs-CRP and LDL-C with Degree of Coronary Artery Stenosis in Patients with Stable Angina Pectoris
hs-CRP LDL-C Coronary artery stenosis Stable angina pectoris
2015/9/21
Background: Over the past decade, several studies have revealed the role of high sensitivity C-reactive protein (hs-CRP), an acute inflammatory marker, as a prognostic factor in the setting of myocard...
EVALUATION OF AUTOANTIBODY AGAINST MODIFIED LDL LEVELS IN PATIENTS WITH CARDIOVASCULAR DISEASES
Autoantibody against OX-LDL cardiovascular diseases
2009/12/29
Background: Atherosclrosis is a process that initiated with hypercholestrolemia and fatty streak formation. Previous studies showed oxidative modification of LDL render immunogenic and autoantibodies ...
EVALUATION OF AUTOANTIBODY AGAINST MODIFIED LDL LEVELS IN PATIENTS WITH CARDIOVASCULAR DISEASES
Autoantibody against OX-LDL cardiovascular diseases
2009/12/29
Background: Atherosclrosis is a process that initiated with hypercholestrolemia and fatty streak formation. Previous studies showed oxidative modification of LDL render immunogenic and autoantibodies ...
The Relation Between Low-Density Lipoprotein (LDL) Oxidation and Hemodialysis with Respect to Membrane Types Protective Effects of Vitamin E-bonded membrane
Oxidative stress hemodialysis antioxidants LDL oxidation
2009/6/26
Plasma total antioxidant (TAO) levels, LDL (low density lipoprotein), antioxidant defense potential (AOP) and the resistance to oxidation of LDL fractions were studied in chronic hemodialysis patients...
冠心病患者外周血炎症相关指标及ox-LDL和ox-LDL抗体的检测及其临床意义
冠心病 急性冠脉综合征 炎症
2009/6/12
冠心病患者外周血炎症相关指标及ox-LDL和ox-LDL抗体的检测及其临床意义。
美乐托宁对ox-LDL诱导的人脐静脉血内皮祖细胞增殖、凋亡及Bcl-2表达的影响。
目的:探讨血凝素样氧化低密度氧化脂蛋白受体1(LOX-1)在氧化低密度氧化脂蛋白(ox-LDL)诱导人肾小球系膜细胞(HGMC)表达转化生长因子(TGFβ1)中的作用。方法:体外培养HGMC,在不同时间加入不同浓度的ox-LDL及LOX-1阻滞性抗体JTX92,用半定量RT-PCR检测细胞LOX-1和TGFβ1 mRNA表达,用Western blot检测细胞LOX-1蛋白合成,用酶联免疫吸附法(...