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Protective Effect of Silymarin on Noise-Induced Hearing Loss in Guinea Pigs
Hearing Loss Noise-Induced Silymarin Auditory Brain Stem Implantation
2015/10/9
Background: Hearing capability plays a principal role on human's communication. Noise-induced hearing loss (NIHL) caused by exposure to high noise levels is a serious socio-economic problem in modern ...
Effect of Local Nasal Immunotherapy on Nasal Blockage in Pollen-Induced Allergic Rhinitis of Guinea Pigs
allergic rhinitis animal model local nasal immunotherapy nasal blockage pollenosis
2010/11/17
Local nasal immunotherapy may be clinically useful for allergic nasal blockage associated with nasal hyperresponsiveness. The mechanisms responsible for this effectiveness might not be related to IgE ...
The Effect of Diclofenac on Tendon Healing: An Experimental Study in Guinea Pigs
Diclofenac Tendon Healing Guinea Pigs
2015/9/14
Background: Whether non-steroidal anti-inflammatory drugs have a detrimental effect on tendon regeneration is still a matter of debate. As such, the purpose of this study is to determine the effect of...
Effects of Theophylline on Chronic Inflammatory Lung Injury Induced by LPS Exposure in Guinea Pigs
airway hyperreactivity COPD goblet cell hyperplasia lipopolysaccharide exposure theophylline
2010/11/18
Repetitive exposure to LPS induced an influx of inflammatory cells into the BALF. Histological changes such as accumulation of inflammatory cells in the lung parenchyma, enlargement of alveoli, swelli...
Effects of olopatadine hydrochloride on the release of thromboxane B2 and histamine from nasal mucosa after antigen-antibody reaction in guinea pigs
allergic rhinitis chemical mediators guinea pigs olopatadine
2010/11/25
Background: Various mediators, such as thromboxane (TX) A2, peptide leukotrienes (P-LT) and histamine, are involved in allergic nasal obstruction. The aim of the present study was to investigate the m...
Role of neutral endopeptidase in endotoxin-induced bronchial hyperresponsiveness to substance P in guinea pigs
active sensitization bronchial hyperresponsiveness endotoxin histamine neutral endopeptidase substance P
2010/11/29
To investigate effects of endotoxin on allergic airway diseases, we studied bronchial responsiveness to histamine (HI) and substance P (SP) in actively sensitized and non-sensitized guinea pigs 24 h a...