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科学家发现DHA调节脑神经发育新机制
二十二碳六烯 神经元质膜 脑神经发育
2022/3/31
二十二碳六烯酸（DHA）是神经元质膜的重要组成部分。在大脑皮层灰质区，DHA主要存在于质膜磷脂，但同时也可在磷脂酶的作用下从膜上释放下来，以游离方式或通过其衍生物参与多种信号转导。
DHA-rich n–3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study
fish oil DHA EPA DNA methylation LINE-1 Alzheimer disease
2018/11/20
Background: Dietary fish oils, rich in long-chain n–3 (ω-3) fatty acids (FAs) [e.g., docosahexaenoic acid (DHA, 22:6n–3) and eicosapentaenoic acid (EPA, 20:5n–3)], modulate inflammatory reactions thro...
Prenatal supplementation with DHA improves attention at 5 y of age: a randomized controlled trial
attention child development fatty acids prenatal supplementation omega-3 fatty acids preschool cognitive development
2018/12/14
Background: Docosahexanoic acid (DHA) is an important constituent of the brain. Evidence from well-designed intervention trials of the long-term benefits of increasing DHA intake during pregnancy has ...
Prenatal supplementation with DHA improves attention at 5 y of age: a randomized controlled trial
attention child development fatty acids prenatal supplementation omega-3 fatty acids preschool cognitive development
2018/12/18
Background: Docosahexanoic acid (DHA) is an important constituent of the brain. Evidence from well-designed intervention trials of the long-term benefits of increasing DHA intake during pregnancy has ...
A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study
DHA EPA inflammation men and women randomized controlled trial risk factors
2018/12/13
Background: To date, most studies on the anti-inflammatory effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in humans have used a mixture of the 2 fatty acids in various forms and...
Maternal single nucleotide polymorphisms in the fatty acid desaturase 1 and 2 coding regions modify the impact of prenatal supplementation with DHA on birth weight
birth weight DHA FADS long-chain PUFAs prenatal supplementation
2018/11/29
Background: Specific single nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene affect the activity and efficiency of enzymes that are responsible for the conversion of polyunsatu...
Long-term effect of high-dose supplementation with DHA on visual function at school age in children born at <33 wk gestational age: results from a follow-up of a randomized controlled trial
docosahexaenoic acid DHA preterm infant very preterm visual processing
2018/11/26
Background: Children born preterm are at risk of visual-processing impairments. Several lines of evidence have contributed to the rationale that docosahexaenoic acid (DHA) supplementation of preterm i...
DHA- Rich Fish Oil Improves Complex Reaction Time in Female Elite Soccer Players
Fatty acids omega 3 efficiency decision-making
2015/5/7
Omega-3 fatty acids (n-3) has shown to improve neuromotor function. This study examined the effects of docosahexaenoic acid (DHA) on complex reaction time, precision and efficiency, in female elite so...
DHA对人肝癌细胞增殖与凋亡的影响及其机制的研究
癌 肝细胞 二十二碳六烯酸类 细胞凋亡
2014/5/11
探讨二十二碳六烯酸（DHA）对人肝癌细胞株Bel-7402增殖和凋亡的影响及其机制。方法：用不同浓度的DHA（0，25，50，100，200 μmol/L）分别作用人肝癌Bel-7402细胞24，48，72 h后，用MTT法检测细胞的增殖情况、Western blot检测Bcl-2和Bax蛋白的表达，并分别用流式细胞仪、real-time PCR和caspase-3活性检测试剂盒检测上述梯度浓度的...
美研究称补充DHA无助减缓老年认知障碍
DHA 老年认知障碍
2010/11/5
很多老年人都服用鱼油保健品，因为其中的主要成分之一DHA是一种对大脑十分重要的成分。但美国一项最新研究却认为，DHA无助于减缓老年轻度至中度认知障碍。