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Evaluation of FcεRI-binding serum IgE in patients with ocular allergic diseases
atopic keratoconjunctivitis ELISA FcεRI FcεRI-binding IgE seasonal allergic conjunctivitis
2010/11/29
We evaluated high-affinity receptor for IgE (FcεRI)-binding serum IgE in patients with atopic kerato- conjunctivitis (AKC; n = 31) and with seasonal allergic conjunctivitis (SAC; n = 13) by enzyme-lin...
Mast cell function modulating IgE-mediated allergy
allergy FcεRI local IgE synthesis mast cell
2010/11/29
Allergic diseases, such as atopic rhinitis, bronchial asthma and urticaria, are prevalent and increasing in frequency. Mast cells are known to play a central role in the immediate phase reaction of al...
Induction of IgE synthesis by genetically modified CD8+ T cells of a patient with adenosine deaminase deficiency
CD40 ligand CD8+ T cells gene therapy IgE production interleukin-4
2010/11/26
We have previously reported that an adenosine deaminase (ADA)-deficient patient treated with T cell-directed gene therapy had an increase in serum IgE levels, despite a marked inversion of the CD4/CD8...
Distribution of specific serum IgE to recombinant pollen allergens (rPhlp1, rPhlp2, rPhlp5, and rBetv2) and their relationship to each other and to their natural counterparts in patients allergic to grass pollen
rBetv2 recombinant allergens rPhlp1 rPhlp2 rPhlp5 timothy grass
2010/11/25
Recombinant pollen allergens rPhlp1, rPhlp2, rPhlp5, and rBetv2 may function as effective markers of atopy and account for a substantial proportion of grass pollen-specific IgE. The purpose of the pre...
Detection of anti-IgE and anti-FcεRI α chain auto-antibodies in patients with atopic dermatitis
atopic dermatitis auto-antibody high affinity IgE receptor immunoglobulin E
2010/11/25
Anti-IgE and anti-FcεRI α chain auto-antibodies have been detected in the sera of atopic and non-atopic subjects; however, the biological activity of these auto-antibodies is still unclear. These two ...
Mold-specific IgE antibodies in relation to exposure and skin test data in schoolchildren
allergy asthma gender IgE moisture problem mold mold sensitization schoolchildren skin prick tests
2010/11/25
Mold-specific IgE was elevated by EIA (> 0.35 IU/mL) to at least one of the 10 studied species in 12 children (39%) with and in two children (3%) without skin test reactions. The calculated prevalence...
Measurement of IgE and IgG4 antibodies against purified grass pollen allergens (Phl p 1, Phl p 2, Phl p 5 and Bet v 2) and natural extracts after short-term grass immunotherapy
grass pollen allergy IgE IgG4 immunotherapy olive pollen recombinant allergens
2010/11/25
We wanted to define allergen-specific antibodies that change due to specific immunotherapy. We conducted a study with grass pollen-allergic patients and compared allergen-specific IgE and IgG4 before ...
Anti-endothelial cell IgE antibodies in children with bronchial asthma
anti-endothelial cell antibodies bronchial asthma IgE
2010/11/24
In the cellular ELISA, the IgE class of AECA was detected significantly more frequently in children with asthma (25/156; 16.0%) than in healthy controls (2/203; 1.0%; P > 0.01). There were no differen...
Attenuation of allergic airway inflammation and associated pulmonary functions by mycobacterial antigens is independent of IgE in a mouse model of asthma
airway hyperresponsiveness asthma Bacillus Calmette-Guérin eosinophils IgE Mycobacterium vaccae
2010/11/24
Neither BCG nor M. vaccae were able to attenuate the EAR, yet both were able to abrogate the parameters used to evaluate the LAR. Interestingly, in neither case were serum or OVA-specific IgE levels r...
Effect of cysteine mutagenesis on human IgE reactivity of recombinant forms of the major rye grass pollen allergen Lol p 1
allergy grass pollen Lol p 1 mutagenesis rye grass
2010/11/24
Background: Hypersensitivity to the group 1 grass pollen allergens is a significant causative factor in the onset of symptoms for hay fever sufferers. To better understand the IgE reactivity of the gr...
Reactivity of IgE in fish-allergic patients to fish muscle collagen
allergen collagen fish muscle parvalbumin
2010/11/24
When 15 sera from fish-allergic patients were subjected to ELISA using bigeye tuna collagen and parvalbumin, 10 sera reacted only to parvalbumin, two reacted only to collagen, two reacted to both coll...
Role of T cells in IgE-dependent triphasic cutaneous reaction caused by dinitrofluorobenzene in the mouse ear: Participation of CD8+ T cells
allergic dermatitis CD4+ T cell CD8+ T cell FK 506 IgE mice triphasic cutaneous reaction
2010/11/24
Whereas the magnitudes of IPR and LPR in BALB/c nu/nu T cell-deficient mice were similar to those in BALB/c +/+ mice, vLPR was not observed in nu/nu mice. In addition, FK 506 (3 and 5 mg/kg) and cyclo...
Regulatory mechanisms of human IgE synthesis
activation-induced cytidine deaminase adaptor molecule germline Cε transcription IgE isotype switching switch recombination machinery
2010/11/24
The induction of allergen-specific IgE synthesis requires the cognate interactions between B and T helper (Th) 2 cells. The B cell-activating signal for IgE synthesis is delivered through interleukin ...
A Photo-immobilized Allergen Microarray for Screening of Allergen-specific IgE
allergen microarray allergen-specific IgE allergy diagnosis chemiluminescence photo-immobilization
2010/11/22
Background: We developed an in vitro system to diagnose allergy using an allergen microarray and photo-immobilization technique. Photo-immobilization is useful for preparing the allergen microarray be...
A Quantitative Immunochromatography Assay of Whole Blood Samples for Antigen-specific IgE -A New Method for Point of Care Testing for Allergens-
Cryptomeria japonica pollen enzyme immunochromatography quantification specific IgE whole blood
2010/11/22
Background: The development of an inexpensive point-of-care testing system for antigen-specific IgE is greatly needed. We, therefore, tried to develop a quantitative enzyme immunochromatography assay ...